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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Histone deacetylase inhibitor
PubChem CID 10095659
Molecular Weight 457.9g/mol
Synonyms

Givinostat hydrochloride, 199657-29-9, Givinostat HCl, Givinostat (hydrochloride), ITF 2357, Z02132R2QQ, ITF2357 Hydrochloride, ITF-2357 Hydrochloride, Histone deacetylase inhibitor, ITF2357, UNII-Z02132R2QQ, Givinostat HCl hydrate, [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrochloride, Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, hydrochloride (1:1), (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride, Carbamic acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, hydrochloride (1:1), MFCD28502062, {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride, ITF 2357 hydrochloride, givinostat monohydrochloride, SCHEMBL23529420, Givinostat hydrochloride anhydrous, CHEBI:231333, EX-A8024, ZHA65729, HY-14842A, AKOS030526700, CS-4728, SB16937, AS-52365, C76335, EN300-257964, P14959, Q27294820, Z2327390266, (6-((Diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride, [6-[(Diethylamino)methyl]-2-naphthalenyl]methyl N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride (1:1), {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate--hydrogen chloride, {6-[(diethylamino)methyl]naphthalen-2-yl}methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride
Drug Type Small molecule
Formula C₂₄H₂₈ClN₃O₄
SMILES CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.Cl
InChI 1S/C24H27N3O4.ClH/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H
InChIKey QKSGNWJOQMSBEP-UHFFFAOYSA-N
CAS Number 199657-29-9
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 93
Ref_1
Pair Name Proanthocyanidin, Histone deacetylase inhibitor
Partner Name Proanthocyanidin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression MMRN1 hsa22915
In Vitro Model T-47D Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0553
MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
Result Their synergism may be closely related to the steroid biosynthesis and extracellular matrix (ECM) receptor interaction pathways. PA + Chi can synergistically inhibit breast cancer cell growth and proliferation, and promote apoptosis. These effects may be related to steroid biosynthesis or the ECM receptor pathway.
Combination Pair ID: 158
Ref_2
Pair Name Celastrol, Histone deacetylase inhibitor
Partner Name Celastrol
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Gene Regulation Up-regulation Acetylation H4K16 KEGG ID N.A.
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
NCI-H1299 Lung large cell carcinoma Homo sapiens (Human) CVCL_0060
LL/2 (LLC1) Malignant tumors of the mouse pulmonary system Mus musculus (Mouse) CVCL_4358
HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
Result Celastrol treatment significantly enhanced the suppressive effects of HDACi on lung cancer cell allografts in mice, with significant H4K16ac upregulation, indicating that a combination of celastrol and HDACi is a potential novel therapeutic approach for patients with lung cancer.
Reversing Drug Resistance
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Combination Pair ID: 612
Ref_3
Pair Name Platycodin D, Histone deacetylase inhibitor
Partner Name Platycodin D
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Down-regulation Phosphorylation CFL1 hsa1072
Up-regulation Expression CYCS hsa54205
Down-regulation Phosphorylation MAPK1 hsa5594
In Vitro Model HA22T/VGH Adult hepatocellular carcinoma Homo sapiens (Human) CVCL_7046
HDACi-R HDACi-R cell line was established from HA22T cells as described previously Homo sapiens (Human) N.A.
Result Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation
03. Reference
No. Title Href
1 The Synergistic Effect of Proanthocyanidin and HDAC Inhibitor Inhibit Breast Cancer Cell Growth and Promote Apoptosis. Int J Mol Sci. 2023 Jun 22;24(13):10476. doi: 10.3390/ijms241310476. Click
2 Celastrol inhibits lung cancer growth by triggering histone acetylation and acting synergically with HDAC inhibitors. Pharmacol Res. 2022 Nov;185:106487. doi: 10.1016/j.phrs.2022.106487. Click
3 Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation. Phytomedicine. 2021 Feb;82:153442. doi: 10.1016/j.phymed.2020.153442. Click
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